The genus Aspergillus encompasses the most common fungi in our environment. Many Aspergillus species are beneficial to humans, but they also include serious animal and plant pathogens. Moreover, most (if not all) Aspergillus species have the ability to produce one or more toxic secondary metabolites called mycotoxins. All Aspergilli produce asexual spores as the main means of dispersion and biosynthesis of certain mycotoxins is intimately related with fungal sporulation. The primary interest of my research program is to understand how fungi coordinate growth, sporulation and toxin biosynthesis employing the model fungus Aspergillus nidulans. We showed that two antagonistic regulatory pathways govern vegetative growth and sporulation in A. nidulans. Vegetative growth is primarily mediated by a heterotrimeric G protein, which stimulates fungal growth while inhibiting asexual/sexual sporulation as well as production of the carcinogenic mycotoxin sterigmatocystin. We found that the initiation, progression and completion of sporulation are directed by the balanced activities of multiple positive and negative regulators. We are further investigating the detailed molecular mechanisms regulating these fundamental biological processes via forward/reverse genetics, genomics and biochemical analyses.

Current projects include:

* Regulatory mechanisms of sporulation and mycotoxin biosynthesis in Aspergillus and Fusarium species.
* Molecular genetics and genomics of fungal growth, sporulation and mycotoxin production.
* Signal transduction in filamentous fungi.

• Microbiology 305: Critical Analyses in Microbiology
• Microbiology 655: Biology and Genetics of Filamentous Fungi
• HHMI Teaching Fellows Program

• Food Research Institute
• Professor, Department of Genetics
• Academic Editor, PLoS ONE
• Graduate Trainer, Genetics, Molecular and Environmental Toxicology Center, Plant Pathology, Food Science.
• Faculty of 1000 Biology, Faculty Member for Microbiology, Microbial Growth & Development Section